What Is Biktarvy?
Biktarvy is a once-daily HIV medication that combines three antiviral drugs into a single pill:
✔ Bictegravir (50mg) – Integrase inhibitor (blocks viral DNA insertion)
✔ Emtricitabine (200mg) – NRTI (stops viral replication)
✔ Tenofovir alafenamide (25mg) – NRTI (reduces viral load)
FDA-approved in 2018, it’s used for:
Newly diagnosed HIV patients
Switching from other HIV meds
NOT for PrEP (HIV prevention)
Table of Contents
How Biktarvy Works
Biktarvy suppresses HIV by:
- Blocking integrase (bictegravir) → Stops virus from inserting into DNA
- Inhibiting reverse transcriptase (emtricitabine & tenofovir) → Prevents viral replication
- Reducing viral load → Helps immune system recover
Key Benefit: One pill, once daily (improves adherence).
Biktarvy Dosage Guide
| Patient Group | Dosage | Key Notes |
|---|---|---|
| Adults | 1 tablet daily | With or without food |
| Children (≥14 kg) | Weight-based dosing | Prescribed by HIV specialist |
| Kidney/Liver Issues | May require adjustment | Avoid if eGFR <30 mL/min |
Important:
✔ Take at the same time daily
✔ Do NOT crush or chew
✔ If missed, take ASAP (unless near next dose)
Common & Serious Side Effects
Common Side Effects (Usually Mild)
- Headache (15-20% of users)
- Diarrhea (10-15%)
- Nausea (8-12%)
- Fatigue (5-10%)
Serious Side Effects (Rare but Dangerous)
- Lactic acidosis (muscle pain, trouble breathing)
- Liver problems (jaundice, dark urine)
- Hepatitis B flare-ups (if co-infected)
- Kidney issues (monitor eGFR)
Seek emergency care if:
- Severe stomach pain
- Yellow skin/eyes
- Unexplained muscle weakness
Biktarvy Drug Interactions
| Avoid With Biktarvy | Reason | Alternative |
|---|---|---|
| Antacids (Tums, Maalox) | Reduces absorption | Take 2 hours before/after |
| Rifampin (TB drug) | Lowers Biktarvy levels | Use alternative HIV meds |
| St. John’s Wort | Speeds up breakdown | Avoid completely |
| Carbamazepine (seizure med) | Reduces effectiveness | Switch to non-interacting med |
Biktarvy vs. Other HIV Meds
| Medication | Pills Per Day | Key Advantage | Biggest Drawback |
|---|---|---|---|
| Biktarvy | 1 | Fewest side effects | Expensive |
| Triumeq | 1 | Cheaper | Risk of allergic reaction |
| Genvoya | 1 | Good for kidneys | Higher tenofovir dose |
| Atripla | 1 | Older, cheaper | CNS side effects (dizziness) |
Biktarvy Cost & Savings Programs
- Retail price: $3,000–$3,800/month
- Covered by: Medicaid, Medicare, most private insurers
- Patient assistance: Gilead Advancing Access (co-pay help)
How to Save:
✔ Use manufacturer coupons
✔ Check 340B programs (if eligible)
✔ Ask about generic alternatives (when available)
FAQs About Biktarvy
1. Can Biktarvy cure HIV?
No, but it controls the virus so well that many reach undetectable viral loads.
2. Is weight gain a side effect?
Some report moderate weight gain, but studies show it’s less than other HIV meds.
3. Can I drink alcohol with Biktarvy?
Yes, in moderation—but heavy drinking hurts liver/kidneys, which Biktarvy also affects.
4. Does Biktarvy cause insomnia?
Rarely (<5% of users). If sleep troubles persist, talk to your doctor.
5. Is Biktarvy safe in pregnancy?
Limited data—consult an HIV specialist if pregnant or planning to be.
