What is Imbruvica?
Imbruvica (generic name ibrutinib) is a prescription medicine used for treating certain types of cancers and immune system diseases.
It belongs to a class of drugs called Bruton’s tyrosine kinase (BTK) inhibitors. It works by blocking signals that help cancer cells grow.
Many people ask: Is Imbruvica chemotherapy?
- The answer is No. It is not traditional chemotherapy, but a targeted therapy that directly attacks cancer cells.
Short Info
| Topic | Key Info |
|---|---|
| Drug Name | Imbruvica (ibrutinib) |
| Class | BTK Inhibitor (targeted therapy) |
| Is it chemotherapy? | No, it’s targeted therapy |
| Main Uses | Leukemia, lymphoma, cGVHD |
| Strength | 140 mg capsules/tablets |
| Side Effects | Diarrhea, bleeding, infection risk, heart rhythm issues |
| Price (2025) | $12,000+ per month in USA |
| Manufacturer | AbbVie & Janssen Biotech |
Table of Contents
Manufacturer of Imbruvica
- Imbruvica Manufacturer: Pharmacyclics LLC (an AbbVie Company) and Janssen Biotech, Inc.
- Dosage forms available: Capsules and tablets.
- Strengths: Commonly prescribed as Imbruvica 140 mg.
Imbruvica Uses
Imbruvica is prescribed for:
- Chronic lymphocytic leukemia (CLL)
- Mantle cell lymphoma (MCL)
- Waldenström’s macroglobulinemia (WM)
- Marginal zone lymphoma (MZL)
- Chronic graft-versus-host disease (cGVHD)
What is Imbruvica prescribed for?
It is mainly used to slow down or stop the growth of cancer cells and manage immune-related conditions.
Mechanism of Action (MOA)
Many people search for Imbruvica MOA.
- It blocks an enzyme called BTK (Bruton’s tyrosine kinase).
- This enzyme is important for cancer cell survival.
- By blocking BTK, Imbruvica stops cancer cells from multiplying and makes them die naturally.
Imbruvica and Immunosuppression
Is Imbruvica an immunosuppressant?
Yes, Imbruvica can weaken the immune system because it interferes with B-cell function. This is why people taking it are at higher risk of infections.
Dosage of Imbruvica
- Standard Dose: Usually 420 mg once daily for CLL and WM.
- MCL Dose: 560 mg once daily.
- Available Strengths: 140 mg capsules or tablets.
- Always take with water at the same time daily.
- Do not crush or chew the capsules.
How long can a person take Imbruvica?
- Many patients take it for months or years, depending on doctor’s advice and treatment response.
Side Effects of Imbruvica
Like all medicines, Imbruvica has side effects.
Common Side Effects:
- Diarrhea
- Tiredness (fatigue)
- Muscle or bone pain
- Bruising easily
- Nausea
Serious Side Effects (need medical help):
- Increased risk of bleeding
- Infections (due to low immunity)
- Heart rhythm problems (atrial fibrillation)
- High blood pressure
- Kidney and liver issues
What are the side effects of Imbruvica?
They range from mild (diarrhea, nausea) to serious (heart problems, bleeding, infections). Always consult your doctor if symptoms worsen.
Warnings and Precautions Before Taking Imbruvica
- Tell your doctor if you have:
- Heart problems
- High blood pressure
- Liver or kidney issues
- Recent surgery or risk of bleeding
- Pregnancy & Breastfeeding: Not recommended.
- Surgery: Stop Imbruvica at least 3–7 days before surgery to reduce bleeding risk.
Drug Interactions of Imbruvica
Imbruvica interacts with several medicines.
Avoid taking with:
- Antifungals: ketoconazole, itraconazole
- Antibiotics: clarithromycin
- Antivirals: ritonavir
- Blood thinners: warfarin
- Herbal products: St. John’s Wort
These may increase side effects or reduce effectiveness. Always inform your doctor about all medicines you take.
Imbruvica Price (2025)
Imbruvica is an expensive medicine. Prices may vary depending on country and dose.
- In the USA: Approx $12,000 – $14,000 per month.
- Some patients use insurance, patient assistance programs, or generic options (when available) to reduce cost.
